chronic oral epigallocatechin-gallate alleviates streptozotocin-induced diabetic neuropathic hyperalgesia in rat: involvement of oxidative stress
نویسندگان
چکیده
due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (egcg), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of egcg on alleviation of hyperalgesia in streptozotocin-diabetic (stz-diabetic) rats. male wistar rats were divided into control, diabetic, egcg-treated-control and diabetic and sodium salicylate (ss)-treated control and diabetic groups. for induction of diabetes, stz was intraperitoneally injected (ip) at a single dose of 60 mg/kg. egcg was orally administered daily at doses of 20 and 40 mg/kg for seven weeks; one week after diabetes induction. finally, hyperalgesia was assessed using standard formalin, hot tail immersion and paw pressure tests. meanwhile, markers of oxidative stress in brain were measured. diabetic rats showed a marked chemical, thermal and paw pressure hyperalgesia, indicating that the development of diabetic neuropathy and egcg treatment at a dose 40 mg/kg significantly ameliorated the alteration in hyperalgesia (p < 0.05) in diabetic rats as compared with untreated diabetics. egcg treatment (40 mg/kg) also significantly decreased diabetes-induced thiobarbituric acid reactive substances formation (p < 0.05) and nitrite (p < 0.05) content and reversed the reduction of antioxidant defensive enzyme superoxide dismutase (p < 0.05). the results may suggest therapeutic potential of egcg for the treatment of diabetic hyperalgesia through the attenuation of oxidative stress.
منابع مشابه
Chronic Oral Epigallocatechin-gallate Alleviates Streptozotocin-induced Diabetic Neuropathic Hyperalgesia in Rat: Involvement of Oxidative Stress
Due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (EGCG), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of EGCG on alleviation of hyperalgesia in streptozotocin-diabetic (STZ-diabetic) rats. Male Wistar rats were divided into control, diabetic, EGCG-treated-control and diabetic and sodium salicylate (SS...
متن کاملChronic Oral Epigallocatechin-gallate Alleviates Streptozotocin-induced Diabetic Neuropathic Hyperalgesia in Rat: Involvement of Oxidative Stress
Due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (EGCG), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of EGCG on alleviation of hyperalgesia in streptozotocin-diabetic (STZ-diabetic) rats. Male Wistar rats were divided into control, diabetic, EGCG-treated-control and diabetic and sodium salicylate (SS...
متن کاملChronic Oral Epigallocatechin-gallate Alleviates Streptozotocin-induced Diabetic Neuropathic Hyperalgesia in Rat: Involvement of Oxidative Stress
Due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (EGCG), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of EGCG on alleviation of hyperalgesia in streptozotocin-diabetic (STZ-diabetic) rats. Male Wistar rats were divided into control, diabetic, EGCG-treated-control and diabetic and sodium salicylate (SS...
متن کاملChronic Oral Pelargonidin Alleviates Streptozotocin-Induced Diabetic Neuropathic Hyperalgesia in Rat: Involvement of Oxidative Stress
Background: Diabetes mellitus in some clinical cases is accompanied with hyperalgesia. In this study, we evaluated the possible beneficial effect of chronic pelargonidin (PG) treatment on hyperalgesia in streptozotocin (STZ)-diabetic neuropathic rat. Methods: Male Wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, PG-treated control, PG (single- and multiple-dose)-trea...
متن کاملchronic oral pelargonidin alleviates streptozotocin-induced diabetic neuropathic hyperalgesia in rat: involvement of oxidative stress
background: diabetes mellitus in some clinical cases is accompanied with hyperalgesia. in this study, we evaluated the possible beneficial effect of chronic pelargonidin (pg) treatment on hyperalgesia in streptozotocin (stz)-diabetic neuropathic rat. methods: male wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, pg-treated control, pg (single- and multiple-dose)-trea...
متن کاملChronic oral pelargonidin alleviates streptozotocin-induced diabetic neuropathic hyperalgesia in rat: involvement of oxidative stress.
BACKGROUND Diabetes mellitus in some clinical cases is accompanied with hyperalgesia. In this study, we evaluated the possible beneficial effect of chronic pelargonidin (PG) treatment on hyperalgesia in streptozotocin (STZ)-diabetic neuropathic rat. METHODS Male Wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, PG-treated control, PG (single- and multiple-dose)-trea...
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عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۱، شماره ۴، صفحات ۱۲۴۳-۱۲۵۳
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